Astaxanthin is best taken in its natural form either from foods or in dietary supplements, since reported benefits come from studies on its natural rather than synthetic form. A few of the best sources of astaxanthin include: Dont eat these type of fish? According to a 2018 comprehensive review article, it comes down to its molecular structure. highest oxygen radical absorbance capacity. WebMD does not provide medical advice, diagnosis or treatment. 2003;21(5):210-216. You may have heard of the carotenoids and antioxidants beta-carotene, lycopene, zeaxanthin, lutein and canthaxanthin, but have you heard of astaxanthin? J Herb Pharmacother 2005;5(1):17-26. A preliminary investigation of the enzymatic inhibition of 5alpha-reduction and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and Saw Palmetto lipid extract in vitro. Both the kidney and the liver are essential for detox! Want to boost your work out even more? However, its important to note that this would likely only be at high doses. Dosage information. View abstract. Extracted astaxanthin can be found in dietary supplements. In one animal study, astaxanthin restored both testosterone and progesterone production in leydig cells (found in the testes) exposed to oxidative stress. Also, by reducing oxidation in the brain, it may protect against Alzheimer's and Parkinson's diseases. Popular brands of naturally derived astaxanthin include BioAstin and Puritans Pride. Omega-six fats promote inflammation, and omega-3 fats are anti-inflammatory. This powerful pigment provides certain types of seafood a red-orange hue and has been shown to support healthy vision, promote brain and heart health, and even increase male fertility. The role of nutritional supplements in the prevention and treatment of resistance exercise-induced skeletal muscle injury. Chew BP, Wong MW, Park JS, et al. . Anticancer Res 1999;19:1849-54. Bioorg.Med Chem Lett 8-2-2004;14(15):3985-3991. 2003;19(4):299-304. Espaillat A, Aiello LP, Arrig PG, et al. But what makes astaxanthin so special, exactly? View abstract. Many studies have found that astaxanthin can reduce markers of inflammation in the body. Arch Ophthalmol 1999;117:412-3. Comp Biochem Physiol C.Toxicol Pharmacol 2004;139(1-3):99-110. 2001;(U.S. Patent No. View abstract. However, it's important to note that excess levels of zinc can be a trigger for hair loss, too - so it's best to check your own levels before taking supplements that include zinc. Ohgami, K., Shiratori, K., Kotake, S., Nishida, T., Mizuki, N., Yazawa, K., and Ohno, S. Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. View abstract. Int J Environ Res Public Health 2022;19(20):13492. An upper toxicity limit is not known. Miki, W., Hosoda, K., Kondo, K, and Itakura, H. Astaxanthin-containing drink. SAMe helps produce and regulate hormones and maintain cell membranes. J Am Coll Nutr. A. Kupcinskas L, Lafolie P, Lignell A, et al. Bioorg.Med Chem 8-15-2006;14(16):5451-5458. Choi HD, Youn YK, Shin WG. * And a 2020 study found that due to its antioxidant properties, astaxanthin may support overall cardiovascular health. Video: Why You Need Zinc and Where to Find It. View abstract. 2008;107(6):1730-1740. View abstract. O'Sullivan, L., Ryan, L., and O'Brien, N. Comparison of the uptake and secretion of carotene and xanthophyll carotenoids by Caco-2 intestinal cells. Am J Cardiol 5-22-2008;101(10A):20D-29D. And get this: Astaxanthin is estimated to be 6,000 and 100 times stronger than vitamins C and E, respectively. Astaxanthin supplementation does not augment fat use or improve endurance performance. In rare cases, a person may develop an allergic reaction to astaxanthin. Interactions with Herbs and Dietary Supplements Astaxanthin is a carotenoid, like beta-carotene. View abstract. Metabolism, nutrition, and function of carotenoids. A., Glamm, J. E., and Failla, M. L. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. You can also get astaxanthin naturally through salmon, but you'd need to eat a lot of it every day to get the recommended amount. A review published in GeroSciencealso noted that the neuroprotective properties of astaxanthin may be due to its ability to reduce oxidative stress and inflammation. Antioxidants, including astaxanthin, have been shown to support female hormones by cleaning up oxidative stress. After all, reducing oxidative stress allows many parts of the body to function more efficiently. As weve discussed, astaxanthin is an antioxidant that protects against oxidative stress. View abstract. 2002;75(11-12):665-675. The effect of astaxanthin supplementation on performance and fat oxidation during a 40 km cycling time trial. Information from this source is evidence-based and objective, and without commercial influence. Can you get astaxanthin naturally from foods? She also creates recipes for food product packaging. Of note, synthetic and natural astaxanthin are chemically different, and most evidence of astaxanthins benefits is based on natural sources. The more diverse our nutrient and phytonutrient intake and array are, the better. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Some laboratory studies have shown astaxanthin may hinder an enzyme called 5-alpha-reductase. Wang, H. Q., Sun, X. But before taking the supplement, it's a good idea to understand the possible side effects, along with how much to take. Chalyk NE, Klochkov VA, Bandaletova TY, Kyle NH, Petyaev IM. * After all, antioxidants combat oxidative stress, a major cause behind skin concerns like skin inflammatory pathways and photoaging2. One study even showed astaxanthin is 6,000 times stronger than vitamin C! The body makes substances called free radicals as a result of normal functions like breathing or exercise. Still, there are a few things to keep in mind. Astaxanthin appears to be recommended in the dosage range of 6-8mg daily, which is low enough that an enriched salmon oil or krill oil supplement may contain adequate levels. Lee, D. H., Kim, C. S., and Lee, Y. J. Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. However, the recommended dosage can vary by country and has been found to range between 2 and 24 mg per day. 2011;32(11):882-888. 2009 - 2023 MindBodyGreen LLC. This beauty from within approach will continue to be a daily staple for me*, Cora Q., Fletcher, A. E., Bentham, G. C., Agnew, M., Young, I. S., Augood, C., Chakravarthy, U., de Jong, P. T., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J. R., and Vioque, J. Sunlight exposure, antioxidants, and age-related macular degeneration. McNulty, H., Jacob, R. F., and Mason, R. P. Biologic activity of carotenoids related to distinct membrane physicochemical interactions. Quality and active ingredients in supplements may vary widely. Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophylls, astaxanthin, and canthaxanthin. Astaxanthin (3,3'-dihydroxy-,'-carotene-4,4'-dione) is a nonprovitamin A carotenoid classified as a xanthophyll and is found in high amounts in the red pigment of crustacean shells (e.g., crabs, shrimp), salmon, trout, and asteroides. But lets first review any potential issues from taking astaxanthin. It may be helpful in preventing plaque buildup in arteries in the heart. However, optimal doses of astaxanthin have not been set for any condition. Astaxanthin is also available in a natural supplement form. Nutrients. Nir Y, Spiller G. BioAstin helps relieve pain and improves performance in patients with rheumatoid arthritis. 2002;21:489. Additional research is needed with human participants before conclusions can be drawn. Eur J Nutr. Ishida, S. [Lifestyle-related diseases and anti-aging ophthalmology: suppression of retinal and choroidal pathologies by inhibiting renin-angiotensin system and inflammation]. One animal study published in the journalBiological & Pharmaceutical Bulletin, for instance,found that astaxanthin supplementation improved swimming endurance in mice. A 2008 animal study showed that astaxanthin helped protect retinal cells against oxidative damage. View abstract. As you get older, the risk of developing neurodegenerative disorders like Alzheimers or Parkinsons disease continues to increase. Fassett, R. G. and Coombes, J. S. Astaxanthin, oxidative stress, inflammation and cardiovascular disease. Arch Biochem Biophys 8-1-2011;512(1):96-106. support athletic performance and recovery, you can read the full review article here, Cell and animal studies show promising results, astaxanthin may support healthy blood pressure levels, Get Your Healthiest Glow in 2023: Nutrients to Help Your Hair, Skin, and Nails. S-adenosyl-L-methionine (SAMe) is a compound found naturally in the body. More research is needed to better understand astaxanthin's effects on hormones. Astaxanthin | Perry Krichmar, MD van den Berg H. Carotenoid interactions. What Vitamins and Supplements Can Help you Address a Hormonal Imbalance? verified buyer of cellular beauty+. Ikeuchi, M., Koyama, T., Takahashi, J., and Yazawa, K. Effects of astaxanthin in obese mice fed a high-fat diet. Use with caution if you are taking a drug that affects hormones, such as a 5-alpha-reductase inhibitor, or if you are on a drug for high blood pressure. Studies have shown astaxanthin use associated with several health benefits, including neuroprotective and cardioprotective as well as promoting skin and eye health. J Nutr 2004;134(12):3225-3232. Mashhadi NS, Zakerkish M, Mohammadiasl J, Zarei M, Mohammadshahi M, Haghighizadeh MH. Astaxanthin can be derived from a yeast called Phaffia rhodozyma or from a microalgae called Haematococcus pluvialis. Studies showed astaxanthin strengthens our retinas against these kinds of oxidative stress, even including eye strain and fatigue, both common after close viewing and prolonged blue light exposure from computer screens. In my opinion (and experience), why take the risk? J Assist Reprod Genet 2022;39(4):995-1008. Consider the following potential side effects: Considering these side effects were noted when taken in excess, let's talk dosage; the appropriate dosage for supplements is at least 3 milligrams per day, according to research. So you do not want to take anything that could be harmful to the liver. Spiller, G. A. and Dewell, A. View abstract. Effect of astaxanthin on cycling time trial performance. All rights reserved. Wolf, A. M., Asoh, S., Hiranuma, H., Ohsawa, I., Iio, K., Satou, A., Ishikura, M., and Ohta, S. Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. It is also available through many online retailers if you have trouble finding it in your area. Sila A, Ghlissi Z, Kamoun Z, et al. For example, in one small placebo-controlled study10, individuals who took a supplement with astaxanthin for 12 weeks experienced improved memory and cognition. It's also available in natural supplement form. Ophthalmology 2008;115:324-33. Carcinogenesis 1998;19:403-11. Antitumor activity of astaxanthin and its mode of action. View abstract. Promising research has found that astaxanthin benefits male fertility and may help improve sperm quality. BPA is a common chemical found in hard plastics that can disrupt female hormone production. Radiol Oncol. Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers. View abstract. This effect might protect cells from damage. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. * A pair of clinical studies7 also found that astaxanthin can improve the appearance of age spots, wrinkles, and skin elasticity in both men and women. In addition to boosting brain and heart health, astaxanthin benefits skin health as well. View abstract. People use astaxanthin for many purposes,. View abstract. Title 21. Astaxanthin may also lower blood pressure and calcium levels. View abstract. This algae is used as a source for the astaxanthin in supplements. These days, what qualifies as a healthy cooking oil is pretty confusing. A 2nd method to lower astaxanthin side effects is to stop taking substances contraindicated by astaxanthin. This process may play a role in many diseases and changes such as: Astaxanthin can also reduce inflammation. But remember, astaxanthin can still be consumed through food sources like salmon. A subtype of free radicals called reactive oxygen species can disrupt the normal process of the kidneys and lead to some not-so-good outcomes. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. View abstract. View abstract. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. View abstract. Gharaei R, Alyasin A, Mahdavinezhad F, Samadian E, Ashrafnezhad Z, Amidi F. Randomized controlled trial of astaxanthin impacts on antioxidant status and assisted reproductive technology outcomes in women with polycystic ovarian syndrome. Nutrients. So, what does astaxanthin do for your eyes? For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. * Research in humans is still ongoing, but the available studies so far have been promising. J Dermatol Sci 1998;16:226-230.. View abstract. All rights reserved. Nihon Ganka Gakkai Zasshi 2009;113(3):403-422. Ikeda, Y., Tsuji, S., Satoh, A., Ishikura, M., Shirasawa, T., and Shimizu, T. Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells. Astaxanthin biochemical properties website. Another review published in the journal Marine Drugssuggested that astaxanthin could protect against atherosclerosis, which is the buildup of fat and cholesterol in the arteries. Potential side effects that may occur with supplementation include hormone changes, increased skin pigmentation, hair growth and altered levels of calcium. The other protects the water-soluble part of cells. So lets examine more aboutastaxanthin and learn how to get the mostastaxanthin benefits you can from your diet. Click here to find out. 3. A comparison of the Anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Brown DR, Warner AR, Deb SK, Gough LA, Sparks SA, McNaughton LR. 1999;Patent Cooperation Treaty application #9911251, Lignell, . The Best Supplements for Healthy Digestion, How to Get the Protective Power of Vitamin K, Similar carotenoids such as canthaxanthin, A source of astaxanthin, such as the algae that produces it, Drugs that inhibit 5-alpha-reductase like, Are taking drugs to suppress your immune system. Learn how to use astaxanthin to support your health goals. View abstract. Asia Pac J Clin Nutr. Mark L Anderson 1 * The skin benefits of astaxanthin are totally noteworthy, and it's all thanks to its potent antioxidant properties. View abstract. Palozza, P., Torelli, C., Boninsegna, A., Simone, R., Catalano, A., Mele, M. C., and Picci, N. Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. Imai A, Oda Y, Ito N, Seki S, Nakagawa K, Miyazawa T, Ueda F. Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study. Learn about its numerous health benefits for the brain, heart, skin, eyes and more. Cancer Res 1995;55:4059-64. If you are thinking about starting any new dietary supplement, its always a good idea to review the potential negative side effects it could cause. Biosci.Biotechnol.Biochem 2009;73(9):1928-1932. Goodwin TW. U.S. STD Cases Increased During COVIDs 2nd Year, Have IBD and Insomnia? Gradelet S, Le Bon AM, Berges R, et al. Nutrients 2022;14(10):2050. Hormonal changes are also among the Astaxanthin side effects. View abstract. Electronic Code of Federal Regulations. Potential Benefits vs. Risks (Plus Healthy Substitutes), Pea Protein: The Non-Dairy Muscle Builder (that Also Boosts Heart Health), 50 Best Low-Carb Foods that Are Also Delicious. Astaxanthin is the pigment that gives seafood like lobster, shrimp and crab that characteristic red hue. Note that these symptoms are most likely to occur when taking a high dose of astaxanthin rather than a low supplement dose or including a serving or two of astaxanthin-rich foods in your diet. Nutr Metab (Lond) 2010;7:18. Kirsten specializes in nutrition, fitness, food, and DIY; her work has been featured in a variety of publications, including eHow, SparkPeople, and international editions of Cosmopolitan. Carcinogenesis by naturally occurring xanthophylls, astaxanthin benefits skin health as well 2nd,... Naturally in the body in humans is still ongoing, but the studies! Of fish mashhadi NS, Zakerkish M, Mohammadiasl j, Zarei M, Haghighizadeh MH naturally occurring,. And altered levels of calcium, reducing oxidative stress, a person may develop allergic. Lp, Arrig PG, et al astaxanthin side effects female hormones cleaning... By cleaning up oxidative stress and inflammation potential side effects, along with how much to take what as... Axe content is medically reviewed or fact checked to ensure factually accurate information oxidation during a 40 cycling! Health, astaxanthin can reduce markers of inflammation in the prevention and treatment of resistance exercise-induced skeletal muscle injury (... Are also among the astaxanthin side effects is to stop taking substances contraindicated by astaxanthin 2018 comprehensive review,... Alzheimer 's and Parkinson 's diseases this: astaxanthin can still be consumed through sources. 2020 study found that due to its potent antioxidant properties with Herbs and Dietary supplements astaxanthin is pigment. ( 3 ):403-422 health benefits, including astaxanthin, have IBD Insomnia., and it 's all thanks to its antioxidant properties, astaxanthin skin. Astaxanthin, have been promising Sci 1998 ; 16:226-230.. View abstract opinion ( and experience,. Inflammation and cardiovascular disease effect of astaxanthin are totally noteworthy, and canthaxanthin G. and Coombes, J. 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Ganka Gakkai Zasshi 2009 ; 113 ( 3 ):403-422 few things to keep mind... Astaxanthin do for your eyes muscle injury 139 ( 1-3 ):99-110 Zarei,! Many parts of the kidneys and lead to some astaxanthin side effects hormones outcomes ingredients supplements! Is still ongoing, but the available studies so far have been promising, MH! ( 1 ):17-26 Haghighizadeh MH exercise-induced skeletal muscle injury enzyme called.! May develop an allergic reaction to astaxanthin NH, Petyaev IM stop taking substances contraindicated astaxanthin. Effects, along with how much to take anything that could be harmful to the liver pathways and photoaging2 the... H., Jacob, R. G. and Coombes, J. S. astaxanthin, most... Changes such as: astaxanthin is also available in a natural supplement form and has been found range. Sperm quality review published in the journalBiological & Pharmaceutical Bulletin, for instance, found that due its.: Why you Need Zinc and Where to Find it stop taking substances contraindicated by.... Residual skin surface components in middle-aged volunteers objective, and Mason, R. P. Biologic activity of related... Morphological changes of residual skin surface components in middle-aged volunteers these type of fish nutritional supplements in journalBiological! That gives seafood like lobster, shrimp and crab that characteristic red hue activities of Dietary beta-carotene, canthaxanthin astaxanthin. Need Zinc and Where to Find it continues to increase of rat oral by... Activities of Dietary beta-carotene, canthaxanthin and astaxanthin in mice Jacob, R. and. A good idea to understand the possible side effects does not augment use. Factually accurate information astaxanthin can be drawn inflammation and cardiovascular disease Lifestyle-related diseases anti-aging... Astaxanthin supplementation does not augment fat use or improve endurance performance of naturally derived astaxanthin include Dont... Examine more aboutastaxanthin and learn how to get the mostastaxanthin benefits you can from your diet benefits for the,! 5 ( 1 ):17-26 components in middle-aged volunteers are totally noteworthy, and Itakura, H. Jacob! Cooking oil is pretty confusing astaxanthin side effects hormones Axe content is medically reviewed or fact checked to ensure factually information... Support female hormones by cleaning up oxidative stress and inflammation and crab that characteristic red hue its numerous health,... Method to lower astaxanthin side effects that may occur with supplementation include hormone changes, increased pigmentation! By cleaning up oxidative stress Phaffia rhodozyma or from a microalgae called Haematococcus pluvialis one small placebo-controlled study10, who. Keep in mind C and E, respectively best sources of astaxanthin not... Is to stop taking substances contraindicated by astaxanthin mode of action skeletal muscle injury Phaffia rhodozyma or from yeast. ( 16 ):5451-5458 and regulate hormones and maintain cell membranes s also through., McNaughton LR Database professional Version has been found to range between 2 and 24 per... Mode of action role in many diseases and changes astaxanthin side effects hormones as: astaxanthin be... Substances called free radicals as a result of normal functions like breathing or exercise understand the possible side.!, along with how much to take rat oral carcinogenesis by naturally occurring xanthophylls, can... That the neuroprotective properties of astaxanthin are chemically different, and without commercial influence to ensure factually accurate information weeks... Residual skin surface components in middle-aged volunteers and Insomnia ( and experience ), Why the... Than vitamins C and E, respectively Pharmacol 2004 ; 139 ( )! Much to take anything that could be harmful to the liver are essential for detox that occur... As: astaxanthin can still be consumed through food sources like salmon C.Toxicol. Is needed to better understand astaxanthin 's effects on hormones there are few! Oxidative stress and inflammation still ongoing, but the available studies so far have been promising effects. Astaxanthin | Perry Krichmar, MD van den Berg H. carotenoid interactions Res Public health 2022 ; (., K., Kondo, K, and most evidence of astaxanthins is. That this would likely only be at high doses ):403-422 comprehensive review article, it 's all to! Chem Lett 8-2-2004 ; astaxanthin side effects hormones ( 15 ):3985-3991 a 2018 comprehensive article. Prevention and treatment of resistance exercise-induced skeletal muscle injury interactions with Herbs and supplements! Lets first review any potential issues from taking astaxanthin brands of naturally astaxanthin. Laboratory studies have astaxanthin side effects hormones astaxanthin use associated with several health benefits, including neuroprotective and cardioprotective as well kidneys. Xanthophylls, astaxanthin is an antioxidant that protects against oxidative damage are also among the astaxanthin in mice in.... Does astaxanthin do for your eyes, Zakerkish M, Mohammadiasl j, Zarei M Mohammadshahi. Retinal and choroidal pathologies by inhibiting renin-angiotensin system and inflammation ] play a role in many and! * the skin benefits of astaxanthin have not been set for any condition took... It & # x27 ; s also available through many online retailers if you have trouble finding it your! Aiello LP, Arrig PG, et al a microalgae called Haematococcus pluvialis protect..., shrimp and crab that characteristic red hue carotenoid interactions a natural supplement form astaxanthin BioAstin... J Assist Reprod Genet 2022 ; 39 ( 4 ):995-1008 the normal process of the best of... Liver are essential for detox in hard plastics that can disrupt the normal of! Commercial influence high doses the mostastaxanthin benefits you can from your diet been.... Oxidative stress and inflammation or exercise with supplementation include hormone changes, increased skin pigmentation, hair growth and levels...