Furthermore, no impact of the two administered ERr 731() doses on the E2 deprivation-induced bone loss has been evident at the end of the study. Rhubarb might harm the liver. Please see our Medical Disclaimer for more information. Der Freie Zahnarzt 1997;9:76-80. [Long-term treating effects of rhubarb and captopril in delaying the progression of renal failure]. Due to its laxative effects, rhubarb may cause stomach discomfort, nausea, vomiting or diarrhea in certain people. View abstract. Diel P, Hertrampf T, Seibel J, Laudenbach-Leschowsky U, Kolba S, Vollmer G. J Steroid Biochem Mol Biol. Rhubarb is rich in antioxidants, particularly anthocyanins (which give it its red color) and proanthocyanidins. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Below is a summary of the existing animal and cell-based studies; they should guide further investigational efforts but should not be interpreted as supportive of any health benefit. The effects of rhubarb alone remain obscure. Is Rhapontic rhubarb the same as black cohosh? Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. For Chinese rhubarb in a crude powder form, a common dosage is 10-30 g/day. No medical claims are implied in this content, and the information herein is not intended be used for self-diagnosis or self-treatment of any condition. **This is a subjective assessment based on the strength of the available informations and our estimation of efficacy. Clinical study of Shengxue Mixture in treating aplastic anemia. We additionally performed densitometry analysis of the proximal tibia metaphysis using peripheral computed tomography (pQCT) and quantified bone homeostasis markers in the serum to examine potential effects on the bone. View abstract. Others have side effects that are sometimes underestimated. Zhang, W. L. [Treatment of hemorrhage of the upper gastro-intestinal tract with the Chinese drug hai huang san. 1991;11(9):547-9, 518. 2009 Nov;117(4-5):176-84. doi: 10.1016/j.jsbmb.2009.09.011. I would warn if you are prone to kidney stones, take a calcium product and keep your water intake up. 2013 Sep;108(9):1400-15; 1416. doi: 10.1038/ajg.2013.218. 1996;109(1):35-37. Thats right, poisonous. During the time when the female body is not having a menstrual cycle, the body may still be releasing those last few eggs. View abstract. Menopause. Am J Chin Med 2005;33(6):839-850. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. Importantly, this supplement didnt alter gynecological factors such as uterus health or bleeding [21]. Combining it with digoxin (Lanoxin, Digox), used for treating heart failure, can be especially dangerous [60]. View abstract. View abstract. Taking rhubarb with other stimulant laxatives might cause more diarrhea and very low potassium levels. Oscaby, F. [A chlorhexidine-rhubarb extract mixture for gingival inflammation]. All four analyses noted that the examined studies had poor methodological quality [28, 36, 47, 25]. 7) Complications of Blood Poisoning (Sepsis), Animal and Cellular Research (Lacking Evidence). Zhao D, Feng SX, Zhang HJ, et al. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Rhubarb has been traditionally used to heal a wide variety of issues such as constipation, fever, inflammation, and kidney failure. 1996;27(4):418-421. ERr 731 also reduced anxiety from moderate-severe to slight, aside from reducing hot flashes in another clinical trial of 109 women transitioning to menopause [24]. Am J Forensic Med Pathol. 2021;1308:309-352. doi: 10.1007/978-3-030-64872-5_22. Nutrition. The reviews for this product are very mixed. Information is shared for educational purposes only. View abstract. The same effect might not be observed in other populations. Your use of this website indicates your agreement to this websites published terms of use and all site policies. It was effective both alone and in combination with a drug for high blood pressure, captopril [15]. As if the hot flashes, mood swings, night sweats and sexual challenges werent enough, now you can add weight gain to the menopausal whammy. Accessibility Phytoestrogens mimic estrogen in the body by binding to estrogen receptors. Both Chinese and common rhubarb, the most common types, are generally considered safe for consumption [7, 59]. Chir Dent.Fr. Many of the Chinese rhubarb articles were conducted in China with Chinese people. Perimenopause is the first stage in this process and can start eight to 10 years before menopause. Some medications can also harm the liver. Papke A, Kretzschmar G, Zierau O, Kaszkin-Bettag M, Vollmer G. J Steroid Biochem Mol Biol. This capsule takes about 28 days to begin to be effective. Chinese rhubarb combined with mineral powder and blood purification was more effective at treating severe herbicide poisoning than the standard procedure. 2013 May;79(7):538-53. doi: 10.1055/s-0032-1328187. Soybeans and the products produced from them, such as tofu and miso, are a great source of phytoestrogens . Fairbairn JW. A review. Taking these products together might cause potassium levels to drop too low. View abstract. Jonathan Ritter, PharmD, PhD (Pharmacology), Relieves menopausal symptoms and menstrual pain, Helps with sepsis and pesticide poisoning, Can cause diarrhea due to laxative effect, Various plant pigments (anthraquinone compounds such as, Laxative phenolic compounds (anthraquinone glycosides such as sennosides), Antioxidant phenolic compounds (catechins), Traditional Chinese Medicine combination remedies (most common). Li, T. [Rhubarb in the treatment of viral hepatitis and its mechanism of action]. PMC [1] Hormone therapy: Is it right for you? Yokozawa, T., Fujioka, K., Oura, H., Nonaka, G., and Nishioka, I. Menopause. I am currently continuing at SunAgri as an R&D engineer. Z., Kang, B., and Zhu, Q. Q. The company claims that the product can reduce the frequency of hot flashes by 80% and menopausal anxiety by 61%. In another trial of 89 critically-ill children, a Chinese herbal remedy (Fuan Liquid) added to conventional drugs successfully reduced gut dysfunction. Flax seeds also contain high amounts of phytoestrogens. View abstract. 2002;22(4):264-266. In 145 patients, a sage and Chinese rhubarb (23 mg/g) topical cream had a similar efficacy as a common herpes medication (Zovirax) at healing herpes sores [50]. stones should also avoid rhubarb due to the oxalate content. Anxiety, stress, brain fog, and hot flashes have diminished. Most of rhubarbs oxalate is in its leaves, so trim them off and discard them, and youre safe. It appears to have some benefits for the treatment of menopause symptoms ( 26 ). This list does not cover all possible side effects. 2021;51(8):916-925. Its active ingredient is rhapontic. In a clinical trial of 45 women, Himalayan rhubarb (1,260 mg, 2x/day) was equally effective at reducing menstrual pain as the painkiller mefenamic acid [52]. Nutrition Reserach 1993;13:1017-1024. Chinese rhubarb is often combined with other herbs and dietary changes to achieve synergistic effects in TCM. They can also kill cancer cells and prevent metastasis by blocking excessive cell division [8, 9]. (Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(10):597-600, 579. The https:// ensures that you are connecting to the 8600 Rockville Pike What are the side effects of rhubarb? It takes about 4 weeks to see a difference in your symptoms. The efficacy of ERr 731 , a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study.Further a recent preclinical study excluded unwanted side effects on the endometrium by showing a lack of stimulation of proliferation marker genes by ERr 731 or . Federal government websites often end in .gov or .mil. You may also try taking a still picture of it with your computers webcam. The extracts were effective against resistant strains, too [58]. Disclaimer: The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. In a study with over 1,000 patients with sepsis, Chinese rhubarb reduced fungal infections, especially when combined with adequate nutrition (via stomach tubes or IV) [37]. In a clinical trial of 80 people, 20 mg/kg rhubarb reduced the incidence of lung toxicity, improved lung function, and reduced levels of inflammatory substances (TGF-beta1 and IL-6) [53]. Russia supplied and controlled the export of the dried root, thus controlling its price. from 1750 to 1850 Russia was making a fortune from trading rhubarb root through st Petersburg to europe via the baltic. [emailprotected] View abstract. In 56 people, Baoyuan Dahuang Decoction, a different rhubarb-containing Chinese mixture improved the quality of life in people with chronic kidney failure [17, 18]. 1993;13(2):71-3, 67. Some women said it didnt work for them, and others said it brought on symptoms or even their period. Hot flashes. Med Clin (Barc). [Clinical study on effect of Chinese herbal medicine combined with hemodialysis in treating uremia]. [Experimental treatment of rhubarb on mesangio-proliferative glomerulonephritis in rats]. Further a recent preclinical study excluded unwanted side effects on the endometrium by showing a lack of stimulation of proliferation marker genes by ERr 731() or its constituents in the 3-day uterotrophic assay. View abstract. View abstract. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. Zheng, F. [Effect of Rheum officinal on the proliferation of renal tubular cells in vitro]. Rhubarb is the name used to describe several plant species in the genus Rheum, native to China, Iran, Turkey, and India. Note: Results may vary about any product effectiveness. Black cohosh side effects include: Stomach upset Rash Cramping Headaches Vaginal spotting or bleeding 2 Potential soy side effects include: The main active ingredient here is organic, but that doesnt mean its not a potent substance. We do not verify or endorse any claims made in these reviews. 2000;20(9):660-663. Yan, M., Zhang, L. Y., Sun, L. X., Jiang, Z. Efficacy and safety of a special extract of Rheum rhaponticum (Err 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. 2020;52:102476. We do not aim to diagnose, treat, cure or prevent any illness or disease. Rhubarb contains oxalate, which causes illness or death when large quantities are ingested. Such symptoms include: hot flashes weight gain low metabolism mood shifts night sweats difficulty concentrating The. Its also important to keep in mind that Rhubarb has laxative action, which is desired in some cases but may cause discomfort in others. Nephrol.Dial.Transplant. Your email address will not be published. Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. Long-term use or use in higher doses can lead to bone loss, muscular weakness, irregular heart rhythm, and potassium loss. These compounds are highly concentrated in the leaves, which should not be consumed [7]. 3 E Evergreen Road #1193, New City, NY 10956 Rhubarb also contains high amounts of dietary fiber that can boost digestive health. Chang JL, Montalto MB, Heger PW, Thiemann E, Rettenberger R, Wacker J. Integr Med (Encinitas). Chinese Kidney Disease Journal 1993;9(4):197-201. I suffered a small bout of kidney stones, which is rare. Consuming 27 g/day of ground rhubarb stalks reduced total and LDL cholesterol by 8 9% in 10 men, but the study lacked a control group [39]. Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. [The efficacy and tolerability of Pyralvex solution and Pyralvex Gel in the treatment of gingivitis. Copyright 2011 Elsevier Ltd. All rights reserved. Information from this source is evidence-based and objective, and without commercial influence. but is for informational and educational purposes alone. In pregnant women with high blood pressure, Chinese rhubarb reduced levels of triglycerides and LDL cholesterol, while increasing levels of HDL cholesterol [41]. Stimulation of ER has been shown to elicit beneficial estrogen-like activities and reduce adverse side effects. Nutrition Research 1998;18(5):893-903. Gastroenterology 2018;154(4):1096-1101. View abstract. Treating Psoriasis With Biologics: What to Know, Symptoms of menopause. At this point some women decide to go for hormone therapy[1], while others look for a more natural solution like a supplement. Zhang, Z. J., Cheng, W. W., and Yang, Y. M. [Low-dose of processed rhubarb in preventing pregnancy induced hypertension]. A: Although you cant buy this product directly through the Estroven website, they list the price as $21.97 down from a previous $29.99. Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A. Observation of therapeutic effect in 50 cases of chronic renal failure treated with rhubarb and adjuvant drugs. For this reason, you should show the product to your doctor and get medical approval before you begin taking it. All of our content is written by scientists and people with a strong science background. The health effects of the other forms of rhubarb have not been studied extensively. View abstract. Taking rhubarb along with "water pills" might make potassium levels drop too low. [Clinical study of shuizhi-dahuang mixture in treating schizophrenics with blood stasis syndrome]. It also relieves you of mental exhaustion while at the same time relieving joint and muscle discomfort. In a clinical trial of 126 people with severe inflammation of the pancreas, the use of Chinese rhubarb powder (15 g, 1 2x/day) with a specific nutrition plan lowered inflammation, disease severity, and liver and kidney damage [26]. OTHER NAME(S): Chinese Rhubarb, Da Huang, Garden Rhubarb, Himalay. it banned the export of the seeds to block the growing of the plant elsewhere. View abstract. We have all heard stories about rhubarb and bad joints and theres a truth in some of the homespun wisdom the plant is high in oxalic acid, which is reputed to inhibit the absorption of iron and calcium and can also aggravate joint problems, such as arthritis. The product relies solely on one active ingredient. The efficacy of ERr 731(), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. View abstract. More than two centuries ago, Native Americans discovered that the root of the black cohosh plant (Actaea racemosa, formerly known as Cimicifuga racemosa) helped relieve menstrual cramps and menopausal symptoms, such as hot flashes, irritability, mood swings, and sleep disturbances. Zhong.Xi.Yi.Jie.He.Za Zhi. They can be eaten all summer long. Rhubarb has been used for centuries and is especially important in Traditional Chinese Medicine (TCM), which considers it a vital remedy for various diseases. 2007 Mar-Apr;14(2):270-83. The parts of rhubarb medicinally used rhizome and roots are generally very safe and cause few side effects. Yang, N., Liu, X., and Lin, Q. Rhapontic rhubarb is used for many of the same reasons as black cohosh, and its the active ingredient in the popular menopause supplement Estroven. Sanada, H. [Study on the clinical effect of rhubarb on nitrogen-metabolism abnormality due to chronic renal failure and its mechanism]. Botanical modulation of menopausal symptoms: mechanisms of action? Epub 2009 Jul 3. View abstract. , Night sweats. Avoid coffee, tea, cola, energy drinks, or other products that contain caffeine. Safety and efficacy of NT, an herbal supplement, in treating human obesity. J Crit Care. The anthraquinone laxatives. In general, regulatory bodies arent assuring the quality, safety, and efficacy of supplements. Xenobiotica. Thats right. More studies are needed to clarify the conflicting results. FOIA Goel, V., Cheema, S. K., Agellon, L. B., Ooraikul, B., and Basu, T. K. Dietary rhubarb (Rheum rhaponticum) stalk fibre stimulates cholesterol 7 alpha-hydroxylase gene expression and bile acid excretion in cholesterol-fed C57BL/6J mice. Planta Med. An official website of the United States government. 2006 Sep-Oct;13(5):744-59. The efficacy of ERr 731(), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. This is the end of a womans reproductive years. Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study. Comment * document.getElementById("comment").setAttribute( "id", "a269cd1e8bbff3968ad1d173ca7d8400" );document.getElementById("a6cbe26769").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. Because rhubarb has a laxative effect, please discuss with your doctor before taking it with any medications. Epub 2005 Sep 1. I have a brand new unopened box of it and if you would like it text me at 412 265-5865 or email me at